The Wang Laboratory

at The State Key Laboratory of Elemento-Organic Chemistry, Nankai University


  • Zi-Yu Zhang, Jie Ren, Ming Zhang, Xiu-Fang Xu, Xiao-Chen Wang*
    Divergent Synthesis of N-Heterocycles by Merging Borane-Mediated Cyclopropane Ring-Opening and Hydride Abstraction"
    Chin. J. Chem., Just accepted. 

  • Jun-Jie Tian,# Ning Liu,# Qi-Fei Liu, Wei Sun, and Xiao-Chen Wang*
    "Borane-Catalyzed Direct Asymmetric Vinylogous Mannich Reactions of Acyclic α,β-Unsaturated Ketones"
    J. Am. Chem. Soc., 2021, 143, 3054-3059. [Link]


  • Zhong Liu, Xian-Shuang Tu, Le-Tao Guo and Xiao-Chen Wang*
    "Aluminum–Catalyzed Tunable Halodefluorination of Trifluoromethyl- and Difluoroalkyl-Substituted Olefins"
    Chem. Sci., 2020, 11, 11548–11553. [Link]

  • Jun-Jie Tian,# Zhao-Ying Yang,# Xin-Shen Liang, Ning Liu, Chen-Yu Hu, Xian-Shuang Tu, Xiang Li, and Xiao-Chen Wang*
    Borane-Catalyzed Chemoselective and Enantioselective Reduction of 2-Vinyl-Substituted Pyridines 
    Angew. Chem. Int. Ed., 2020, 59, 18452-18456. [Link]

  • Ya-Lin Zhang, Rui-Ting Guo, Heng Luo, Xin-Shen Liang, and Xiao-Chen Wang*
    "Convergent Synthesis of Dihydropyrans from Catalytic ThreeComponent Reactions of Vinylcyclopropanes, Diazoesters, and Diphenyl Sulfoxide"
    Org. Lett. 2020, 22, 5627-5632. [Link]
  • Yu-Quan Zhao, Jun-Jie Tian, Chong-Ren Ai and Xiao-Chen Wang*
    "Diiodomethane-Mediated Generation of N-Aryliminium Ions and Subsequent [4 + 2] Cycloadditions with Olefins."
    J. Org. Chem. 2020, 85, 2456-2465 [Link]

  • Rui-Ting Guo, Ya-Lin Zhang, Jun-Jie Tian, Ke-Yu Zhu and Xiao-Chen Wang*
    "Rhodium-Catalyzed ortho-Selective Carbene C–H Insertion of Unprotected Phenols Directed by a Transient Oxonium Ylide Intermediate."
    Org. Lett. 2020, 22, 908-913 [Link]


  • Zhi-Yun Liu,# Ming Zhang,#and Xiao-Chen Wang*
    ''Hydrosilylation-Promoted Furan Diels–Alder Cycloadditions
    with Stereoselectivity Controlled by the Silyl Group''

    J. Am. Chem. Soc.,  2020, 142, 581-588 [Link]

  • Xin-Shen Liang, Rui-Dong Li, and Xiao-Chen Wang* 
    "Copper-Catalyzed Asymmetric Annulation Reactions of Carbenes with 2-Iminyl- or 2-Acyl-Substituted Phenols: Convenient Access to Enantioenriched 2,3-Dihydrobenzofurans"

    Angew. Chem. Int. Ed.  2019, 58, 13885 –13889

  • Jun-Jie Tian,# Ning-Ning Zeng,# Ning Liu, Xian-Shuang Tu,  and Xiao-Chen Wang*

    “Intramolecular Cyclizations of Vinyl-Substituted N,N-Dialkyl Arylamines Enabled by Borane-Assisted Hydride Transfer”

    ACS Catal. 2019, 9, 295-300[Link] 


  • Ya-Lin Zhang,# Rui-Ting Guo,#Jia-Hao He, and Xiao-Chen Wang* 
    "Catalytic Intermolecular Coupling of Rhodacyclopentanones with Alcohols Enabled by Dual Directing Strategy"
     Org. Lett. 2019, 214239-4244 [Link]

  • Xiang Li,#Jun-Jie Tian,# Ning Liu, Xian-Shuang Tu, Ning-Ning Zeng, and Xiao-Chen Wang*

    "Spiro Bicyclic Bisborane Catalysts for Metal-Free Chemoselective and Enantioselective Hydrogenation of Quinolines"

    Angew. Chem. Int. Ed. 2019, 58, 4664-4668. [Link]    


  • Xian-Shuang Tu, Ning-Ning Zeng, Ru-Ye Li, Yu-Quan Zhao, De-Zhen Xie, Qian Peng* and Xiao-Chen Wang*
    "C2-Symmetric Bicyclic Bis-Borane Catalysts: Kinetic or Thermodynamic Products from a Reversible Hydroboration of Dienes"
    Angew. Chem. Int. Ed. 2018
    57, 15096-15100. [Link]


  • Zhi-Yun Liu, Zhi-Hui Wen, and Xiao-Chen Wang*
    "B(C6F5)3-Catalyzed Cascade Reduction of Pyridines"
    Angew. Chem. Int. Ed. 201756, 5817-5820 [Link]

  • Zi-Yu Zhang,Zhi-Yun Liu,# Rui-Ting Guo, Yu-Quan Zhao, Xiang Li, and Xiao-Chen Wang*
    "B(C6F5)3-Catalyzed Ring Opening and Isomerization of Unactivated Cyclopropanes"
    Angew. Chem. Int. Ed.
    2017, 56, 4028-4032 [Link]


  • Brandon E. Haines, Xiao-Chen Wang, Jin-Quan Yu and Djamaladdin G. Musaev
     "Mechanistic Details of the Pd(II)-Catalyzed C-H Iodination by Iodine Molecule: Oxidative Addition vs Electrophilic Cleavage" 
     J. Am. Chem. Soc.  2015, 137, 9022.  [Link]

  • Xiao-Chen Wang, Wei Gong, Li-Zhen Fang, Ru-Yi Zhu, Suhua Li, Keary M. Engle and Jin-Quan Yu
    "Ligand-enabled meta-C-H activation using a transient mediator"
    Nature 2015, 519, 334. [Link]


  • Xichen Xu, Xiaochen Wang, Yuxiao Liu, Michael P Doyle*
    “Enantioselective Carbonyl-ene Reactions Catalyzed by Chiral Cationic Dirhodium(II,III) Carboxamidates”
     J. Org. Chem.2014, 79 (24), 12185-12190. [Link]

  •  Ru-Yi Zhu, Jian He, Xiao-Chen Wang, Jin-Quan Yu*
     “Ligand-Promoted Alkylation of C(sp3)–H and C(sp2)–H Bonds” 
    J. Am. Chem. Soc.2014136 (38), 13194–13197. [Link]


  • Xiao-Chen Wang, Yi Hu, Samuel Bonacorsi, Yang Hong, Richard Burrell, and Jin-Quan Yu*
    “Pd(II)-catalyzed C–H Iodination Using Molecular I2 as the Sole Oxidant”
    J. Am. Chem. Soc.2013135 (28), 10326–10329.  [Link]
  •  Ling Chu, Xiao-Chen Wang, Curtis E. Moore, Arnold L. Rheingold, and Jin-Quan Yu*
    “Pd-catalyzed Enantioselective C–H Iodination: Asymmetric Synthesis of Chiral Diarylmethylamines” 
    J. Am. Chem. Soc., 2013, 135 (44), 16344–16347. [Link]


  •  Xiaochen Wang, Quentin M. Abrahams, Peter Y. Zavalij and Michael P. Doyle*
    “Highly Regio- and Stereoselective Dirhodium Vinylcarbene-induced Nitrone Cycloaddition with Subsequent Cascade Carbenoid Aromatic Cycloaddition/N-O Cleavage and Rearrangement”
    Angew. Chem., Int. Ed. 201251 (24), 5907–5910.  [Link]
  • Yu Qian, Xinfang Xu, Xiaochen Wang, Peter Y. Zavalij, Wenhao Hu and Michael P. Doyle*
    "Rhodium(II) and Copper(II) Catalyzed Reactions of Enoldiazoacetates with Nitrones. Metal Carbene versus Lewis Acid Directed Pathways”
    Angew. Chem., Int. Ed. 2012, 51 (24), 5900–5903. [Link]


  • Hong Chen,* Song Zuo, Xiaochen Wang, Xiaowei Tang, Ming Zhao, Yanling Lu, and Liting Chen
     “Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents.”
    Eur. J. Med. Chem.2011, 46, 4709-4714. [Link]
  •  Xiaochen Wang, Carolin Weigl, and Michael P. Doyle*
    “Solvent Enhancement of Reaction Selectivity: A Unique Property of Cationic Chiral Dirhodium Carboxamidates”
    J. Am. Chem. Soc., 2011, 133 (24), 9572–9579. [Link]
  •   Xiaochen Wang, Xinfang Xu, Peter Y. Zavalij and Michael P. Doyle*
    “Asymmetric Formal [3+3]-Cycloaddition Reactions of Nitrones with Electrophilic Vinylcarbene Intermediates”
    J. Am. Chem. Soc., 2011, 133 (41), 16402–16405. [Link]


  •  Jian-Hua Xie, Sheng Liu, Wei-Ling Kong, Wen-Ju Bai, Xiao-Chen Wang, Li-Xin Wang and Qi-Lin Zhou*
    “Highly Enantioselective and Diastereoselective Synthesis of Chiral Amino Alcohols by Ruthenium-Catalyzed Asymmetric Hydrogenation of α-Amino Aliphatic Ketones” 
    J. Am. Chem. Soc.2009131 (12), 4222–4223. [Link]
  • Xiaochen Wang, Zhuoyan Li and Michael P. Doyle*
    “Barriers to Enantiocontrol in Lewis Acid Catalyzed Hetero-Diels–Alder Reactions”
    Chem. Commun., 2009, 5612-5614. [Link]